PHA767491 HCl ( CAY-10572 hydrochloride )

产品货号. M19277 CAS No. 942425-68-5

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

PHA767491 HCl
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PHA-767491 是一种有效的 ATP 竞争性双重 Cdc7/CDK9 抑制剂 (IC50: 10/34 nM)。
产品描述

PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK2, 100-fold selectivity against CHK2 and PLK1.
体外实验

——
体内实验

——
同义词

CAY-10572 hydrochloride
通路

Endocrinology/Hormones
靶点

Reductase
受体

Cdk1| Cdk2| Cdk9| Cdc7| GSK-3β
研究领域

Cancer
适应症

——

1. Montagnoli A, et al. Nat Chem Biol, 2008, 4(6), 357-365.

计算器

产品手册

关联产品

Tolrestat

Tolrestat 是一种有效的醛糖还原酶抑制剂 (IC50 = 35 nM)。
WJ-39

WJ-39 is an orally active aldose reductase (AR) inhibitor that ameliorates renal lesions in diabetic nephropathy through activation of Nrf2 signaling, and may be used to ameliorate renal insufficiency and fibrosis.WJ-39 inhibits oxidative stress and inhibits the activation of the inflammatory vesicle of the oligomerization structural domain-like receptor family, pyrin structural domain 3 (NLRP3).
BYAKANGELICIN(b)

BYAKANGELICIN 是一种分离的主要呋喃香豆素成分，其特征为醛糖还原酶抑制剂，可有效治疗糖性白内障和糖尿病性神经病变，因此可能可用作开发临床新型药物的先导化合物。